Bovine papillomavirus genome elicits skin tumours in transgenic mice
- 1 August 1986
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 322 (6080) , 609-612
- https://doi.org/10.1038/322609a0
Abstract
Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA.This publication has 13 references indexed in Scilit:
- Identification of the signal molecules produced by wounded plant cells that activate T-DNA transfer in Agrobacterium tumefaciensNature, 1985
- Wounding and Its Role in RSV-Mediated Tumor FormationScience, 1985
- Autocrine growth factors and cancerNature, 1985
- Tumour induction in the rodent Mastomys natalensis by activation of endogenous papilloma virus genomesNature, 1984
- Biology and biochemistry of papillomavirusesPublished by Springer Nature ,1984
- Transformation and replication in mouse cells of a bovine papillomavirus--pML2 plasmid vector that can be rescued in bacteria.Proceedings of the National Academy of Sciences, 1982
- Tumorigenesis at a Predetermined Oral Site After One Intraperitoneal Injection of N -Nitroso- N -MethylureaScience, 1982
- Activation of non-expressed bovine papilloma virus genomes by tumour promotersNature, 1982
- Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cellCell, 1980
- High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virusNature, 1978