Quasispecies and the development of new antiviral strategies
- 1 January 2003
- book chapter
- Published by Springer Nature
- Vol. 60, 133-158
- https://doi.org/10.1007/978-3-0348-8012-1_4
Abstract
RNA virus populations consist of complex and dynamic mutant distributions, rather than defined genomic sequences. This feature confers great adaptability on viruses and is partly responsible for current difficulties of viral disease prevention and control. Mutant distributions, also termed mutant swarms or mutant clouds, were first proposed in a theory of molecular evolution termed quasispecies theory. The theoretical formulation of quasispecies and its links to present day RNA viruses are discussed. The need to accommodate antiviral strategies to the dynamic nature of viral populations is emphasized. In particular, recent results on viral extinction associated with enhanced mutagenesis (virus entry into error catastrophe) are reviewed and presented as an example of how the understanding of viruses as quasispecies could lead to a potential practical application in medicine.Keywords
This publication has 88 references indexed in Scilit:
- Dynamic fitness landscapes in molecular evolutionPhysics Reports, 2001
- Evolution of digital organisms at high mutation rates leads to survival of the flattestNature, 2001
- Natural selection: a phase transition?Biophysical Chemistry, 2000
- Mutation, Competition and Selection as Measured with Small RNA MoleculesPublished by Elsevier ,1999
- QUASISPECIESPublished by Elsevier ,1999
- Our Cosmic OriginsPublished by Cambridge University Press (CUP) ,1998
- On the nature of virus quasispeciesTrends in Microbiology, 1996
- The HypercyclePublished by Springer Nature ,1979
- Nucleotide sequence heterogeneity of an RNA phage populationCell, 1978
- Selforganization of matter and the evolution of biological macromoleculesThe Science of Nature, 1971