Conversion of penicillins into biosynthetically significant peptides
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 14,p. 609-610
- https://doi.org/10.1039/c39780000609
Abstract
Mild acid treatment of the 4-mercapto-azetidin-2-one (1) gave the thioaldehyde (2) which was intercepted by reduction to the peptide (5), prior to enolization; a similar sequence with the dihydro-derivative (11) provided the cysteinyl-valine peptide (7), which represents a formal reversion of penicillin biosynthesis.This publication has 2 references indexed in Scilit:
- Preparation of a penicillin-derived 4-mercaptoazetidin-2-oneJournal of the Chemical Society, Chemical Communications, 1978
- Synthesis of .beta.,.gamma.-unsaturated amino acidsThe Journal of Organic Chemistry, 1977