Amyloid goiter

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Abstract
Amyloid goiter (AG), defined by the presence of amyloid within the thyroid in such quantities as to produce a clinically apparent enlargement of the gland, is a rare pathologic entity associated with both primary amyloidosis, a syndrome in which there is deposition of insoluble proteinaceous, amorphous and eosinophilic material in the exracellular matrix of some organs, and secondary amyloidosis, which occurs as a result of the accumulation of amyloid A (AA), which is a portion of the acute-phase serum amyloid A (SAA) protein produced by the liver at times of inflammation. In autopsy-based studies intrathyroidal amyloid is present in approximately 80% of patients with secondary amyloidosis and in 50% of those with primary amyloidosis.1 x 1 Von Rokitansky, C. Lehrbuch der pathologischen Anatomie. Vol. 1. 3rd ed. W. Braumuller, Vienna; 1855 (p. 326–8) Google Scholar See all References