2‐Nucleos‐5′‐O‐yl‐4H‐1,3,2‐benzodioxaphosphinin‐2‐oxide—ein neues Konzept für lipophile, potentielle Prodrugs biologisch' aktiver Nucleosidmonophosphate
- 5 January 1996
- journal article
- zuschrift
- Published by Wiley in Angewandte Chemie
- Vol. 108 (1) , 77-79
- https://doi.org/10.1002/ange.19961080112
Abstract
Eine nichtenzymatische, hydrolytische Tandemreaktion setzt selektiv aus den Nucleosidphosphotriestern 1 und 2 die 5′‐phosphorylierten Derivate der antiviral aktiven NucleosidAnaloga ddT und d4T frei. Die Hydrolyse von 1 und 2 ließ sich durch die Substituenten X steuern. Somit sollten sich Verbindungen des Typs 1 und 2 prinzipiell als Prodrug‐Formen phosphorylierter Nucleoside eignen. magnified imageKeywords
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