On the Stereochemical Divergence in the Conjugate Addition of Lithium Dimethylcuprate/Trimethylsilyl Chloride to γ-Alkoxy and γ-Ureido α,β-Unsaturated Esters
- 1 January 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1991 (12) , 1083-1089
- https://doi.org/10.1055/s-1991-28396
Abstract
A comparative study was made of the reaction of chiral non-racemic γ-alkoxy and γ-ureido-α,β-unsaturated esters with lithium dimethylcuprate in the presence of trimethylsilyl chloride. The possible origins of the anti- and syn-additions respectively are discussed and rationalized.Keywords
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