Increased Follicle-Stimulating Activity in the Plasma of Ovariectomized Rats.

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Abstract
Follicle-stimulating activity was detected in blood plasma of adult female castrate rats as early as 7 days post-operative by injection of plasma into immature hypophysectomized female rats for a 4-day period. Follicle-stimulating activity continued to increase slowly but progressively as the postoperative interval increased to a 4 months' period. With this bioassay method no direct evidence for circulating interstitial cell-stimulating activity was found at the highest dosage level tested.