PRODUCTION OF LAUDANOSINE FOLLOWING INFUSION OF ATRACURIUM IN MAN AND ITS EFFECTS ON AWAKENING
Open Access
- 1 July 1989
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 63 (1) , 76-80
- https://doi.org/10.1093/bja/63.1.76
Abstract
Twenty patients were given maximal doses of atracurium or vecuronium by infusion during surgery. Anaesthesia was maintained with an infusion of thiopentone, nitrous oxide and fentanyl. In patients administered atracurium, the plasma laudanosine concentration at cessation of surgery was 0.34 (SD 0.22) μg ml−1; there was little tendency to cumulate during operation. A 20% higher arterial concentration of thiopentone was found at awakening in patients given atracurium, suggesting CNS stimulation by laudanosine, although the effect is too modest to be of clinical significance.Keywords
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