P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor
- 22 July 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 572 (1-3) , 167-171
- https://doi.org/10.1016/j.febslet.2004.06.097
Abstract
We have identified an activator of Rac, P-REX2, that is structurally related to the exchange factor PtdIns(3,4,5)-dependent Rac exchanger (P-REX1), but exhibits distinct tissue-specific expression. P-REX2 is spliced into two RNA species, approximately 3.5 and approximately 10 kb in size. The cDNA corresponding to the smaller transcript encodes a protein that exhibits strong similarity with P-REX1 within its N-terminal domains, but differs in the C-terminal region. P-REX2 promoted increased levels of GTP-bound Rac that could be further stimulated by enhancing PI-3K activity. Thus, P-REX2 may serve as a novel link between Rac activation and the PI-3 kinase pathway.Keywords
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