Mutagenicity of betel quid and its ingredients using mammalian test systems
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (4) , 501-503
- https://doi.org/10.1093/carcin/5.4.501
Abstract
The mutagenic potential of betel quid and its ingredients (known colloquially as PAN) were tested in 2 short term mutagenicity assays, the micronucleus test [mouse erythrocytes] and a mammalian gene mutation test [Chinese hamster lung fibroblast V-79 cells]. Betal quid with tobacco [Nicotiana tabacum], tobacco, betel nut and one of its alkaloids arecoline were positive in both tests. Extracts of betel quid and arecaidine (a metabolite of arecoline present in Betel nut) were negative. The data presented correlate well with previous tumorigenicity data on these compounds.This publication has 9 references indexed in Scilit:
- Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: Betel quid chewersCancer Letters, 1982
- Tetracycline-induced mutation in cultured Chinese hamster cellsMutation Research/Genetic Toxicology, 1982
- Chromosome-damaging activity of saliva of betel nut and tobacco chewersCancer Letters, 1982
- Chromosome-breaking ability of arecoline, a major betel-nut alkaloid, in mouse bone-marrow cells in vivoMutation Research Letters, 1982
- Morphological transformation, sister chromatid exchange and mutagenesis assay of betel constituentsToxicology Letters, 1981
- Detection of nitrosamines in a commonly used chewing tobaccoFood and Cosmetics Toxicology, 1981
- TUMORIGENIC EFFECT OF AQUEOUS AND POLYPHENOLIC FRACTIONS OF BETEL NUT IN SWISS STRAIN MICE1980
- Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nutBritish Journal of Cancer, 1979
- Chromosome-damaging effect of betel leafMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978