6'"-Deamino-6'"-hydroxy derivatives,as intermediates in the biosynthesis of neomycin and paromomycin.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (5) , 536-543
- https://doi.org/10.7164/antibiotics.34.536
Abstract
From broths of a neomycin producing Streptomyces fradiae and of a mutant of S. rimosus f. paromomycinus, respectively, 6''''''-deamino-6''''''-hydroxyneomycin and 6''''''-deamino-6''''''-hydroxyparomomycin were obtained and their structures established by mass and 13C-NMR spectroscopy and by the study of hydrolytic fragments. These new compounds, which are both present as 2 epimers at C-5'''''', are suggested as intermediates in the biosynthesis of the parent antibiotics. The place and the mechanism of the 5''''''-epimerization and of the 6''''''-amination are discussed.This publication has 5 references indexed in Scilit:
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