QUINACRINE-BLOCKED DESENSITIZATION OF ADRENOCEPTORS AFTER IMMOBILIZATION STRESS OR REPEATED INJECTION OF ISOPROTERENOL IN RATS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 216  (2) , 334-338
Abstract
Repeated forced immobilization or repeated administration of isoproterenol reduces the number of .beta.-adrenoceptors in the heart and spleen of rats. Isoproterenol, but not immobilization, reduced the number of .beta.-receptors in the lung. These changes in .beta.-adrenoceptors were prevented by administration of quinacrine, a phospholipase A2 inhibitor, but the drug had no effect on .beta.-adrenoceptors when given alone. Immobilization, but not isoproterenol, reduced the number of .alpha.-1 adrenoceptors in the heart but had no effect on the lung. Quinacrine treatment decreased the number of .alpha.-1 receptors in heart and lung but increased .alpha.-2 receptors in the spleen. The changes in receptor number attending exposure to agonists are usually consistent with the expected changes. The effects of quinacrine on such changes suggest that phospholipids are involved in modulating the changes in number of receptors or their availability to interact with ligands.

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