Elevated myelin basic protein levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia.

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Abstract
CSF was examined from 70 children with acute lymphoblastic leukemia from evidence of active myelin breakdown based on the release of myelin basic protein (MBP). Asymptomatic children were followed from diagnosis with serial MBP determinations. Of the 53 children, 8 (15.1%) had abnormal elevations of MDP, 6 of 8 before receiving presymptomatic CNS therapy. Long-term observations are in progress. For comparison, 6 children with clinical and radiologic findings of leukoencephalopathy had abnormal MBP determinations; no abnormalities were detected in 11 children with meningeal leukemia.