URINARY KALLIKREIN IN EXPERIMENTAL RENAL-DISEASE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 34  (6) , 616-622
Abstract
Urinary kallikrein excretion was studied in 2 types of experimentally induced renal disease: antiglomerular basement membrane nephritis (20 rats) and aminonucleoside nephrosis (5 rats) with appropriate controls (23 rats) for a period of 6-9 wk following disease induction. In both models there was a prompt significant decrease (P < 0.01-0.001) in urinary kallikrein excretion associated with proteinuria but unrelated to urinary Na and K excretion and urinary volumes. In antiglomerular basement membrane nephritis the kallikrein excretion occurred within the 1st 24 h concurrent with the onset of proteinuria. In aminonucleoside nephrosis the decrease antedated the onset of proteinuria by 48 h beginning within the 1st 24 h following injection of the aminonucleoside. Kallikrein inhibitors were not demonstrable in the urines of diseased animals from either model. The mechanism of the decrease in kallikrein excretion in immune and nonimmune glomerular disease associcated with proteinuria is unknown.