Pyrimidine derivatives and related compounds. Part 48. Uracil ring transformation: conversion of 5-nitrouracils into 5-carbamoyluracils
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1859-1861
- https://doi.org/10.1039/p19840001859
Abstract
1,3-Disubstituted 5-nitrouracils (1) react with malonamide in ethanolic sodium ethoxide to afford 1-substituted 5-carbamoyluracils (3)via rearrangement of the N(3)–C(4)–C(5) portion of the uracil. This ring transformation has been applied to the preparation of 2′,3′,5′-tri-O-acetyl-5-carbamoyluridine (8).This publication has 2 references indexed in Scilit:
- Pyrimidines. 17. Novel pyrimidine to pyridine transformation reaction. One-step synthesis of pyrido[2,3-d]pyrimidinesThe Journal of Organic Chemistry, 1981
- Pyrimidines. 14. Novel pyrimidine to pyrimidine transformation reactions and their application to C-nucleoside conversions. A facile synthesis of pseudoisocytidineThe Journal of Organic Chemistry, 1978