Bone marrow transplantation in multiple myeloma
- 1 February 1986
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 36 (2) , 176-179
- https://doi.org/10.1111/j.1600-0609.1986.tb00824.x
Abstract
We report 3 cases of allogeneic bone marrow transplantation in multiple myeloma that we have recently performed. Following conditioning treatment with i.v. cyclophos‐phamide (60 mg/kg/d, for 2 d), oral melphalan (1.0 mg/kg/d, for 5 d), i.v. BCNU (5.5 mg/kg, in a single dose) and total body irradiation (10 Gy in a single fraction) we observed in all 3 cases the disappearance both of serum M component and of monoclonal bone marrow plasma cells. 1 patient died of acute GVH disease, grade IV, at 2 months, while the other 2 patients are in good health and in unmaintained complete remission at 4 and 20 months, respectively. The usefulness of allogeneic bone marrow transplantation in the management of multiple myeloma is emphasized.Keywords
This publication has 4 references indexed in Scilit:
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- HIGH-DOSE MELPHALAN FOR MULTIPLE MYELOMAThe Lancet, 1983
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- Improved survival times in multiple myeloma treated with melphalan, prednisone, cyclophosphamide, vincristine and BCNU: M-2 protocolThe American Journal of Medicine, 1977