THE EFFECT OF PROLACTIN ON SOME PURINE METABOLIZING ACTIVITIES1

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Abstract
Hypophysectomized, oophorectomized rats were injected with prolactin for two weeks. Comparisons with similar rats which received no prolactin, with normal rats and with rats 19–20 days pregnant, showed that prolactin suppressed xanthine oxidizing activity, and that the suppression was more pronounced in mammary tissue than in liver tissue. The loss in xanthine oxidizing activity was accompanied by an accumulation of nitrogen, ribonucleic acid, and deoxyribonucleic acid in the mammary gland. Although injections of prolactin brought the xanthine oxidizing activity to a level which was quite abnormal, they simply maintained the normal levels of adenosine deaminating and guanosinc phosphorylating activities, preventing the decrease in these activities which follows hypophysectomy-oophorectomy.