Effect of Co++, Ni++, and Zn++ on Corticoid Excretion by the Guinea Pig.

Abstract
Several divalent ions were administered intraperitoneally to guinea pigs, at a dose of 4 umoles/100 g body weight. Urinary corticoid excretion over a 6-hr. period was doubled by Co++, Ni++, and Zn++. Fe++, Cu++, Hg++ and Pb++ produced little or no effect upon corticoid excretion.