Use of substituted phenol as phosphate protecting group in the synthesis of deoxyribo-oligonucleotides bearing 5′-phosphomonoester end group
- 1 January 1970
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications
- No. 2,p. 91-92
- https://doi.org/10.1039/c29700000091
Abstract
A new and efficient approach, which involves the applications of substituted phenols, (i) as 5′-phosphate protecting group and (ii) to increase the binding property of the nucleotidic fragment to benzoylated DEAE-cellulose, has been developed successfully for the synthesis of deoxyribo-oligonucleotides.Keywords
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