In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals
Open Access
- 1 August 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 46 (2) , 287-290
- https://doi.org/10.1093/jac/46.2.287
Abstract
The in vitro susceptibility of 38 strains of Francisella tularensis (biovar F. tularensis palaearctica) was determined using Etests on cysteine heart agar plates with 2% haemoglobin. All strains were susceptible to the antibiotics traditionally used to treat tularaemia, such as streptomycin (MIC90 4.0 mg/L), tetracycline (MIC90 0.38 mg/L) and chloramphenicol (MIC90 0.38 mg/L), and to aminoglycosides, such as tobramycin (MIC90 1.5 mg/L) and gentamicin (MIC90 1.0 mg/L). The quinolones examined had low MIC90s: ciprofloxacin, 0.016 mg/L; levofloxacin, 0.016 mg/L; grepafloxacin, 0.047 mg/L; and trovafloxacin, 0.032 mg/L. In contrast, all the strains were resistant to β-lactams and azithromycin. Quinolones thus seem to be promising drugs for the treatment of tularaemia.Keywords
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