Effect of Repeated Doses of Hydroflumethiazide on Renal Excretion of Electrolytes and Uric Acid in Healthy Subjects

Publisher Website
Google Scholar
Abstract
Urinary excretion of electrolytes and uric acid was investigated in 6 healthy subjects during repeated oral administration of 100 mg hydroflumethiazide [a diuretic, HFT] daily for 7 days, and related to urinary thiazide excretion. Mean 24 h urinary excretion of Na and Cl- increased 100% (P < 0.02) after the first HFT-dose, whereas 24 h excretion values were at control level after the 4th and 7th doses. Mean 24 h urinary K excretion was increased by 31% after the 1st HFT-dose (P < 0.05) and by 47% after the 4th dose (P < 0.05). After HFT was discontinued, mean urinary excretion rates of Na and Cl- dropped to 30% and that of K to 70% of control. In the state of fluid deficiency and elevated aldosterone concentration, there was a significant positive correlation between log excretion rate of HFT and excretion rate of Na (r = 0.68, P < 0.002) calculated from excretion data 0-6, 6-12 and 12-14 h after the 7th dose. After the first dose of HFT, Na excretion was also significantly correlated to log excretion rate of HFT (r = 0.86, P < 0.001) but was probably influenced by other factors as well. Mean serum concentration of uric acid increased significantly, but mean 24 h urinary excretion of uric acid was constant during HFT-treatment.

This publication has 12 references indexed in Scilit: