EFFECT OF PITRESSIN INJECTIONS UPON THE SERUM ELECTROLYTES AND WATER EXCHANGE OF CATS WITH DIABETES INSIPIDUS AND ADRENAL INSUFFICIENCY

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Abstract
Cats with diabetes insipidus have normal conc. of serum Na, K, and chloride. Pitressin inj., in dosage adequate to control the polyuria of diabetes insipidus, does not affect the concs. of Na, K or chloride in the serum of normal or of diabetes insipidus cats. In adrenal insufficiency, untreated polyuric cats have a very short survival time, and do not show the usual decrease in serum Na and chloride but if pitressin is administered, diabetes insipidus cats have a survival time about the same as ordinary adrenalectomized animals, and show the usual changes in serum Na and chloride. Ordinary adrenalectomized cats lose more Na than chloride from the serum during the insufficiency period; cats treated with pitressin after adrenalectomy appear to lose Na and chloride in approximately equivalent amts. Pitressin adm. to ordinary adrenalectomized cats does not affect the survival time. All the cats showed negative daily water balance following adrenal removal, but in no case was the total water loss great enough in itself to account for the death of the animal. Abnormalities in internal fluid shifts are probably more important in causing death than changes in the water balance of the whole organism.

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