Polymorphism at the G6PD and 6PGD loci inDrosophila melanogaster
- 1 June 1978
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 31 (3) , 227-237
- https://doi.org/10.1017/s0016672300018012
Abstract
The influence of sodium octanoate on the polymorphism at the loci G6PD and 6PGD in Drosophila melanogaster was investigated by studying its effect on egg hatchability, larval-to-adult survival and adult survival. The results demonstrate the existence of differences in fitness between the different genotypes of the two loci both for larval-to-adult survival and for adult survival. Furthermore, changes in enzyme activity of both enzymes, brought about by the sodium octanoate treatment, were observed. This makes it highly probable that the observed differences in fitness can be ascribed to the loci themselves and not to linked fitness genes. Finally, this study demonstrates the existence of strong interaction between the two loci with respect to fitness. Epistasis was demonstrated both in the larval-to-adult survival experiment and in the adult survival experiment.Keywords
This publication has 16 references indexed in Scilit:
- Polymorphism at the G6PD and 6PGD loci inDrosophila melanogaster: I. Evidence for selection in experimental populationsGenetics Research, 1977
- Investigations on the organization of genetic loci in Drosophila melanogaster: lethal mutations affecting 6-phosphogluconate dehydrogenase and their suppressionMolecular Genetics and Genomics, 1977
- LINKAGE DISEQUILIBRIUM BETWEEN FUNCTIONALLY RELATED ENZYME LOCI OFDROSOPHILA MOJAVENSISCanadian Journal of Genetics and Cytology, 1976
- Role of the pentose phosphate pathway in metabolism of Drosophila melanogaster elucidated by mutations affecting glucose 6‐phosphate and 6‐phosphogluconate dehydrogenasesFEBS Letters, 1976
- Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratiosBiochemical and Biophysical Research Communications, 1976
- Regulation of the oxidative NADP-enzyme tissue levels inDrosophila melanogaster. I. Modulation by dietary carbohydrate and lipidJournal of Experimental Zoology, 1976
- General two-locus selection models: Some objectives, results and interpretationsTheoretical Population Biology, 1975
- The pentose shunt in wild‐type and glucose‐6‐phosphate dehydrogenase deficient Drosophila melanogasterJournal of Experimental Zoology, 1974
- Regulation of gluconeogenesis and glycolysis: Studies of mechanisms controlling enzyme activityAdvances in Enzyme Regulation, 1967
- Glucose-6-Phosphate Dehydrogenase in Drosophila : X-Linked Electrophoretic VariantsScience, 1964