Abnormal MRI signal in the rigid form of Huntington's disease.
Open Access
- 1 October 1991
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 54 (10) , 888-891
- https://doi.org/10.1136/jnnp.54.10.888
Abstract
Eighteen patients with Huntington's disease (HD) were examined with MRI. Eleven had the common hyperkinetic form, seven had the rigid variant. All seven patients with rigid HD had increased signal intensity in the neostriatum in intermediate and T2-weighted images. Only one hyperkinetic HD had similar findings. In all the other cases, signal abnormalities were questionable or absent. Histological differences that account for differences in signal intensity may therefore lie in the caudate nucleus and putamen. Age of onset may be important, since the rigid patients were younger. Follow up studies may help in understanding these signal differences.Keywords
This publication has 6 references indexed in Scilit:
- Striatal and nigral neuron subpopulations in rigid Huntington's disease: Implications for the functional anatomy of chorea and rigidity‐akinesiaAnnals of Neurology, 1990
- Clinical and neuropathologic assessment of severity in Huntington's diseaseNeurology, 1988
- Study of movement disorders and brain iron by MRAmerican Journal of Roentgenology, 1987
- Huntington's disease: Survival of large striatal neurons in the rigid variantAnnals of Neurology, 1984
- Huntington diseaseNeurology, 1979
- THE RIGID FORM OF HUNTINGTON'S DISEASEJournal of Neurology, Neurosurgery & Psychiatry, 1961