Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress
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Open Access
- 1 February 2000
- journal article
- research article
- Published by Wiley in Molecular Microbiology
- Vol. 35 (3) , 542-552
- https://doi.org/10.1046/j.1365-2958.2000.01721.x
Abstract
In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an intracellular reducing environment, substituting for the glutathione–glutathione reductase system found in most other or...Keywords
This publication has 40 references indexed in Scilit:
- Genetic Manipulation of KinetoplastidaParasitology Today, 1999
- How do Protozoan Parasites Survive inside Macrophages?Parasitology Today, 1999
- A Unique Cascade of Oxidoreductases Catalyses Trypanothione-Mediated Peroxide Metabolism in Crithidia fasciculataBiological Chemistry, 1997
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.Proceedings of the National Academy of Sciences, 1996
- Site-Directed Mutagenesis of the Redox-Active Cysteines of Trypanosoma cruzi Trypanothione ReductaseEuropean Journal of Biochemistry, 1995
- Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over‐express trypanothione reductaseEuropean Journal of Biochemistry, 1993
- Active site of trypanothione reductaseJournal of Molecular Biology, 1992
- Cysteine is an essential growth factor for Trypanosoma brucei bloodstream formsMolecular and Biochemical Parasitology, 1992
- Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma bruceiMolecular and Biochemical Parasitology, 1987
- Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in TrypanosomatidsScience, 1985