Imipramine Hydrochloride Intoxication

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Abstract
IMIPRAMINE HYDROCHLORIDE (Tofrānil) is a dibenzazepine closely related to chlorpromazine in its chemical structure, but having a quite different pharmacologie action. Imipramine was found to have a specific effect in dispelling depression. In 1957 Kuhn published the first paper on the treatment of depressive states with imipramine. Its exact mode of action is as yet not clearly defined. Its most useful action has been in periodic endogenous depressive states, in which it often eliminates the need for electroconvulsive therapy or markedly reduces the number of shock treatments needed. The recommended adult dosage is 75 to 100 mg. daily in divided amounts. This may be increased according to response and tolerance, but generally it is not necessary to exceed 200 mg. daily. In the early investigative work, side effects described were: sweating, dryness of the mouth, giddiness, tachycardia, constipation, urinary frequency or retention, disturbances of accommodation, fine and coarse tremors, and

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