Low-Dosage131I Therapy of Thyrotoxicosis (Diffuse Goiters)

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Abstract
RADIOACTIVE iodine therapy effectively controls hyperthyroidism in the majority of patients treated. However, the subsequent appearance of hypothyroidism in some1 has been of increasing concern. There is a cumulative incidence of hypothyroidism after radioiodine that may affect a large percentage of patients 10 years after therapy.2 3 4 Hypothyroidism may also appear in an appreciable number of patients after subtotal thyroidectomy, reported as 28 per cent by Nofal and Beierwaltes, with similar results by others.4 5 6 Indeed hypothyroidism may follow as a late sequel to Graves's disease regardless of the type of therapy and has been considered part of the natural history of . . .