Positive Selection Can Create False Hotspots of Recombination

Open Access

1 March 2006

journal article
Published by Oxford University Press (OUP) in Genetics

Vol. 172 (3) , 2011-2014
https://doi.org/10.1534/genetics.105.052183

Abstract

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

Keywords

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