False-Negative Bromsulfalein Tests

Publisher Website
Google Scholar
Abstract
ALTHOUGH it is widely used in evaluation of hepatic function, the validity of the bromsulfalein test has been questioned since with the standard clinical procedure1 results are occasionally negative in the presence of established liver disease. Normal values in these cases could be due to errors in dosage, improper sampling time, extrahepatic removal of the dye or preservation of bromsulfalein removal capacity despite other evidence of hepatic dysfunction. The present study was undertaken to investigate further the reason the bromsulfalein test may fail to indicate active liver disease in certain patients. Bromsulfalein and indocyanine green plasma-decay patterns, hepatic extraction, muscle . . .