In Vivo Incorporation of Labeled Acetate into Liver and Serum Lipids of Rate on Different Dietary Regimens

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Abstract
Incorporation of intravenously injected 1-14C-acetate into lipids of liver and serum was studied in suckling rats and in rats fed commercial or semisynthetic diets containing no added fat, 15% butter, or 15% corn oil. Incorporation into liver cholesterol was higher on commercial than on semisynthetic diets and was stimulated by addition of corn oil to either diet. Incorporation into fatty acids did not parallel incorporation into cholesterol in the different dietary groups. Serum lipids tended to show a pattern of labeling similar to that of liver. Suckling rats showed low incorporation into both cholesterol and fatty acids. In general, these results correspond to the findings of earlier in vitro studies.

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