A Comparison of Insulin Treatment with and without Added Carbohydrate in Human Diabetic Ketosis12

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Abstract
The fall in the total blood ketones in diabetic acidosis during insulin therapy with and without the addition of carbohydrate was measured. A direct comparison of therapies was accomplished by inducing ketosis 20 times in 8 diabetic patients. The blood ketone levels fall more rapidly following intraven. glucose and fructose than with saline in insulin treated patients with diabetic ketosis. No significant difference in the rate of fall of blood ketones was found between glucose and fructose. When insulin was omitted, intraven. fructose was less effective in lowering blood ketones in 1 patient. Hyperglycemia was less prolonged and glycosuria was smaller after intraven. fructose than glucose in insulin treated patients with diabetic ketosis.