Antibacterial activity of palmitoyltuberactinamine N and di-.BETA.-lysylcapreomycin IIA.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (12) , 1729-1734
- https://doi.org/10.7164/antibiotics.36.1729
Abstract
Palmitoyltuberactinamine N (Pal-Tua N) and di-.beta.-lysylcapreomycin IIA (di-.beta.-Lys-Cpm IIA), synthetic derivatives of the antituberculous agent tuberactinomycin (Tum) and capreomycin (Cpm), respectively, were tested for antibacterial activity. Pal-Tua N inhibited tuberactinomycin-resistant Mycobacterium smegmatis, Escherichia coli, Corynebacterium diphtheriae, Staphylococcus aureus and Streptococcus pyogenes, and had no activity against M. tuberculosis. Di-.beta.-Lys-Cpm IIA inhibited the growth of laboratory-derived Tum-resistant M. smegmatis and M. tuberculosis as well as Tum-resistant M. tuberculosis from patients, with 1 exceptional case.This publication has 1 reference indexed in Scilit:
- Activity of Di-β-Lysyl-Capreomycin IIA and Palmitoyl Tuberactinamine N Against Drug-Resistant Mutants with Altered RibosomesAntimicrobial Agents and Chemotherapy, 1981