Xlf1 Is Required for DNA Repair by Nonhomologous End Joining in Schizosaccharomyces pombe
- 1 February 2007
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 175 (2) , 963-967
- https://doi.org/10.1534/genetics.106.067850
Abstract
The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle. Xlf1 is the ortholog of budding yeast Nej1 and human XLF/Cernunnos proteins.Keywords
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