Effect of Acetazolamide on Passage of Protein from Cerebrospinal Fluid to Plasma.

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Abstract
Comparison of the transfer of radioactivity from CSF to plasma in control dogs and dogs treated with acetazolamide indicated that acetazolamide inhibited the passage of protein from CSF to plasma. Less than half the normal amount of intrathecally injected radioactivity can be accounted for in the blood stream after 24 hours in dogs given acetazolamide. In addition, acetazolamide was also shown to retard the passage of protein from the CSF of dogs having artificially elevated CSF protein levels.