Mechanical effects of liriodenine on the left ventricular‐arterial coupling in Wistar rats: pressure‐stroke volume analysis

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Abstract
In a recent in vivo study, liriodenine, an aporphine alkaloid, has been identified as a prominent anti‐arrhythmic agent that can prevent rats' sudden deaths, even at the dose as low as 10−7 g kg−1. The aim of this study was to determine whether liriodenine at its effective anti‐arrhythmic dose of 10−7 g kg−1 had effects on the left ventricular (LV)‐arterial coupling in Wistar rats. LV pressure and ascending aortic flow signals were recorded to construct the ventricular and arterial end‐systolic pressure‐stroke volume relationships to calculate LV end‐systolic elastance (Ees) and effective arterial volume elastance (Ea), respectively. The optimal afterload (Qload) determined by the ratio of Ea to Ees was used to measure the optimality of energy transmission from the left ventricle to the arterial system. Liriodenine at the dose of 10−7 g kg−1 showed no significant changes in basal heart rate (HR), cardiac output (CO), LV end‐systolic pressure (Pes), Ea, Ees, and Qload. By contrast, liriodenine at the dose of 10−6 g kg−1 produced a significant fall of 2.0% in HR and a significant rise of 5.8% in CO, but no significant change in Pes. Moreover, liriodenine administration of 10−6 g kg−1 to rats significantly decreased Ees by 8.5% and Ea by 10.6%, but did not change Qload. We conclude that liriodenine at the dose of 10−7 g kg−1 has no effects on the mechanical properties of the heart and the vasculature and the matching condition for the left ventricle coupled to its vasculature in rats. Even at 10 times the effective anti‐arrhythmic dose, liriodenine shows no effects on the efficiency of energy transferred from the left ventricle to the arterial system. British Journal of Pharmacology (2001) 133, 29–36; doi:10.1038/sj.bjp.0704036