Simvastatin Reduces the Association of NMDA Receptors to Lipid Rafts
- 1 April 2008
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 39 (4) , 1269-1275
- https://doi.org/10.1161/strokeaha.107.498923
Abstract
Background and Purpose— Excess brain extracellular glutamate induced by cerebral ischemia leads to neuronal death, mainly through overactivation of N-methyl-d-aspartate (NMDA) receptors. The choles...Keywords
This publication has 31 references indexed in Scilit:
- Lipid raft microdomains and neurotransmitter signallingNature Reviews Neuroscience, 2006
- Discontinuation of Statin Treatment in Stroke PatientsStroke, 2006
- Simvastatin prevents oxygen and glucose deprivation/reoxygenation‐induced death of cortical neurons by reducing the production and toxicity of 4‐hydroxy‐2E‐nonenalJournal of Neurochemistry, 2006
- Statins and StrokeJournal of Cerebral Blood Flow & Metabolism, 2005
- Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post‐synaptic densities following transient global ischemia in the rat brainJournal of Neurochemistry, 2005
- Neuroprotective effects of atorvastatin against glutamate‐induced excitotoxicity in primary cortical neuronesJournal of Neurochemistry, 2005
- Protection by cholesterol‐extracting cyclodextrins: a role for N‐methyl‐d‐aspartate receptor redistributionJournal of Neurochemistry, 2005
- Association of Excitatory Amino Acid Transporters, Especially EAAT2, with Cholesterol-rich Lipid Raft MicrodomainsJournal of Biological Chemistry, 2004
- Prediction of Malignant Course in MCA Infarction by PET and MicrodialysisStroke, 2003
- Limiting Ischemic Injury by Inhibition of Excitatory Amino Acid ReleaseJournal of Cerebral Blood Flow & Metabolism, 1993