The repair of DNA damage: Recent developments and new insights
- 1 January 1981
- journal article
- research article
- Published by Wiley in Journal of Supramolecular Structure and Cellular Biochemistry
- Vol. 16 (1) , 91-103
- https://doi.org/10.1002/jsscb.1981.380160109
Abstract
This brief review presents the salient features of new developments in the enzymatic repair of base damage to DNA. DNA glycosylases and apurinic/ apyrimidinic (AP) endonucleases are reviewed and evidence is presented that in at least two prokaryote systems incision of UV-irradiated DNA occurs by the sequential action of these two classes of enzymes. In contradistinction, the uvrA, uvrB, and uvrC gene products of E coli appear to function as a multiprotein complex that catalyzes hydrolysis of phosphodiester bonds in damaged DNA directly. The inducible rapid repair of O6- methylguanine in E coli is also reviewed.Keywords
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