Magnesium Intake in Relation to Risk of Colorectal Cancer in Women
Open Access
- 5 January 2005
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 293 (1) , 86-89
- https://doi.org/10.1001/jama.293.1.86
Abstract
Magnesium is required for a wide range of biological functions. Apart from being essential for the maintenance of genomic stability and for DNA repair, magnesium has a crucial role in modulating cell proliferation, cell cycle progression, and cell differentiation.1 Magnesium supplementation has been demonstrated to reduce the incidence of experimentally induced colon cancer in animals,2,3 which might be related to a decrease in colonic epithelial cell proliferation.3-6 Magnesium has an important role in maintaining the antioxidative status of the cell1; animals deficient in magnesium display an increased susceptibility to oxidative stress.1,7,8Keywords
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