Pulsatile Pressure-Regulated Coronary Perfusion During Ventricular Fibrillation

1 July 1972

journal article
research article
Published by American Medical Association (AMA) in Archives of Surgery

Vol. 105 (1) , 36-41
https://doi.org/10.1001/archsurg.1972.04180070034006

Abstract

Flow-regulated vs pressure-regulated and pulsatile vs nonpulsatile coronary perfusion in the fibrillating heart were studied in dogs. Conventional total cardiopulmonary bypass was employed and coronary perfusion was achieved via the aortic root. The coronary sinus and right and left ventricles were separately cannulated for drainage and blood sampling for the calculation of oxygen consumption and coronary vascular resistance. It was found that thebesian shunt flow fluctuated widely during coronary perfusion. When shunt flow increased suddenly, flowregulated coronary perfusion could not meet the flow requirements, resulting in inadequate perfusion, in contrast to pressureregulated perfusion. With pulsatile coronary perfusion it was found that (1) fluctuation of thebesian shunt flow was less, and (2) myocardial oxygen consumption and coronary vascular resistance were more stable than with nonpulsatile coronary perfusion.

Keywords

This publication has 1 reference indexed in Scilit:

The effect of excessively high perfusion pressures on the histology, histochemistry, birefringence, and function of the myocardium
The Journal of Thoracic and Cardiovascular Surgery, 1969