SERUM-TESTOSTERONE DURING ORAL ADMINISTRATION OF TESTOSTERONE IN HYPOGONADAL MEN AND TRANSSEXUAL WOMEN

Publisher Website
Google Scholar
Abstract
Testosterone [T] tablets of crystal size 2-5 .mu.m were administered orally for 10 days to 3 human subjects with low endogenous serum T (se-T) levels. Fifty mg T increased se-T slightly, while 1 daily dose of 200 mg maintained the se-T level within the normal male range for more than 12 h. No cumulative effect was seen. Seven other subjects with low androgen levels ingested 100 or 200 mg T of crystal size 125-400 .mu.m. Blood samples were taken frequently during the 24 h period following administration of the T and se-T levels were determined. T levels in serum increased in 6 patients and were maintained within the normal male range for 5-7 h. In 1 subject a slight but significant increase in se-T was observed, although the level did not reach the normal male range. Although it is possible to use orally administered T to maintain se-T levels in the normal male range, the convenience to the patient must be balanced against the cost and possible side effects of the large doses required.

This publication has 2 references indexed in Scilit: