The higher order structure of chicken erythrocyte chromosomes in vivo

Abstract
Low-angle X-ray scattering was used to investigate the organization of chicken erythrocyte chromosomes in vivo and to account for the previously observed inconsistencies in many X-ray and EM observations. Chicken erythrocyte chromosomes have a 400 .ANG. periodicity due to a nuclear structure that is directly related to the 300 .ANG. side-by-side packing of chromosome fibers revealed by EM of embedded cells. This periodicity can be preserved in isolated nuclei provided that the proper buffers are used.

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