Kinetics of edema formation in rats as influenced by critical doses of dextran

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Abstract
The severity and time of edema formation is characteristically influenced by doses of dextran if injected intravenously into rats. The dose-response curve revealed that small doses of dextrans (0.1–0.8 mg/100 gm) provoke maximal edema formation within 10 minutes, while increasing doses produce less severe edema and delay in its appearance, until a critical dose is arrived at, which provokes no hyperemia and no edema at all. Further increase in dose provokes edema again. The critical dose is relatively sharp and characteristic for each type of dextrans. If antihistamines are injected simultaneously with the critical dose, edema appears with full intensity. Experiments suggest that dextrans contain two fractions with opposite effects, one which provokes the edema formation and another which inhibits the response.

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