Regulation and mechanisms of mammalian double-strand break repair
Top Cited Papers
- 28 August 2003
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 22 (37) , 5792-5812
- https://doi.org/10.1038/sj.onc.1206679
Abstract
The double-strand break (DSB) is believed to be one of the most severe types of DNA damage, and if left unrepaired is lethal to the cell. Several different types of repair act on the DSB. The most important in mammalian cells are nonhomologous end-joining (NHEJ) and homologous recombination repair (HRR). NHEJ is the predominant type of DSB repair in mammalian cells, as opposed to lower eucaryotes, but HRR has recently been implicated in critical cell signaling and regulatory functions that are essential for cell viability. Whereas NHEJ repair appears constitutive, HRR is regulated by the cell cycle and inducible signal transduction pathways. More is known about the molecular details of NHEJ than HRR in mammalian cells. This review focuses on the mechanisms and regulation of DSB repair in mammalian cells, the signaling pathways that regulate these processes and the potential crosstalk between NHEJ and HRR, and between repair and other stress-induced pathways with emphasis on the regulatory circuitry associated with the ataxia telangiectasia mutated (ATM) protein.Keywords
This publication has 288 references indexed in Scilit:
- DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationNature, 2003
- ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damageOncogene, 2002
- A Ku Bridge over Broken DNAStructure, 2001
- Implication of DNA-Dependent Protein Kinase in an Early, Essential, Local Phosphorylation Event during End-Joining of DNA Double-Strand Breaks in VitroBiochemistry, 1998
- Multiple possible sites of BRAC2 interacting with DNA repair protein RAD51Genes, Chromosomes and Cancer, 1998
- p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thryroid cellsOncogene, 1997
- Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 proteinOncogene, 1997
- p53 Protein Exhibits 3′-to-5′ Exonuclease ActivityCell, 1996
- Single Base-Pair Deletions Induced by Bleomycin at Potential Double-strand Cleavage Sites in the aprt Gene of Stationary Phase Chinese Hamster Ovary D422 CellsJournal of Molecular Biology, 1994
- Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasiaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1981