Recent interest in psychopharmacology has led to extensive investigation of a number of types of drugs. The derivative of ergot known asd-lysergic diethylamide, or LSD-25, is one of the most thoroughly studied. This substance has been known to have pronounced effects upon the uterus, vagina, and bronchi and to cause mydriasis, tachycardia, rise in temperature, and other autonomic effects.1Hoffman,2in 1943, was the first to report psychic effects of the drug, after he had accidentally ingested a small quantity of it. These have been found to include mood changes, schizoid states, and, most important from the ophthalmological standpoint, visual hallucinations. The doses required for production of hallucinations in man are extremely minute, as little as 0.5μg. to 1.0μg. per kilogram of body weight being effective.3Larger doses are required in schizophrenic patients.4 Recently Apter and Pfeiffer5reported their observation that upon administration