Ageing and medicine
Open Access
- 1 February 2000
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 247 (2) , 159-167
- https://doi.org/10.1046/j.1365-2796.2000.00621.x
Abstract
Grimley Evans J (University of Oxford, Oxford, UK). Ageing and medicine (Review). J Intern Med 2000; 247: 159–167. Throughout the world, populations are ageing. The response of the health services needs to be based on a knowledge of the nature of human ageing and the principles of rational health care for older people. Ageing comes about from interactions between intrinsic (genetic) and extrinsic (environment and lifestyle) factors. Health care has to be responsive to the general needs of older people, but also to recognize the heterogeneity produced by different rates and patterns of individual ageing. There are now real possibilities of improving the course of human ageing through modulation of both intrinsic and extrinsic processes. There is also a need to adapt social institutions to what is a permanent change in demography.Keywords
This publication has 50 references indexed in Scilit:
- Genes That Determine Both Thermotolerance and Rate of Aging in Caenorhabditis elegansaAnnals of the New York Academy of Sciences, 1998
- Telomeres and Senescence: Ending the DebateScience, 1998
- daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegansScience, 1997
- A C. elegans mutant that lives twice as long as wild typeNature, 1993
- Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)Journal of Zoology, 1993
- Role of Glycation in AgingAnnals of the New York Academy of Sciences, 1992
- Beneficial Six-Year Outcome of Smoking Cessation in Older Men and Women with Coronary Artery DiseaseNew England Journal of Medicine, 1988
- The mortality of centenarians in England and WalesArchives of Gerontology and Geriatrics, 1985
- Effectiveness of a Geriatric Evaluation UnitNew England Journal of Medicine, 1984
- Predictions of the somatic mutation and mortalization theories of cellular ageing are contrary to experimental observationsJournal of Theoretical Biology, 1981