Spermidine in Hormone-Dependent Differentiation of Mammary Gland in vitro
- 5 April 1974
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4132) , 78-80
- https://doi.org/10.1126/science.184.4132.78
Abstract
Stiulation of milk-protein synthesis in mouse mammary epithelium in vitro requires insulin, hydrocortisone, and prolactin. The requirement for hydrocortisone can be replaced by spermidine. The possibility that spermidine mediates the effect of glucocorticoid is also supported by the observation that the cellular spermidine concentration increases before the accelerated synthesis of casein and α-lactalbumin.Keywords
This publication has 10 references indexed in Scilit:
- An Early Effect of Prolactin on the Formation of α-Lactalbumin by Mouse Mammary Epithelial CellsJournal of Biological Chemistry, 1973
- Polyamine biogenesis in the rat mammary gland during pregnancy and lactationBiochemical Journal, 1972
- Spermine synthesis in the uterus of the ovariectomized rat in response to oestradiol-17βBiochemical Journal, 1972
- The Dynamics of Synthesis and Degradation of Polyamines in Normal and Regenerating Rat Liver and BrainJournal of Biological Chemistry, 1970
- Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growthBiochemical Journal, 1970
- Polyamines and glutathione in tissues of lactating rats (Rattus rattus) and in the Rd/3 ascites tumourComparative Biochemistry and Physiology, 1968
- The Hormonal Control of Lactose Synthetase in the Developing Mouse Mammary GlandJournal of Biological Chemistry, 1968
- Stimulation of polyamine synthesis in relation to nucleic acids in regenerating rat liverBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- Polyamines and nucleic acids during development of the chick embryoBiochemical Journal, 1965
- Hormone-dependent differentiation of mammary gland in vitro.Proceedings of the National Academy of Sciences, 1965