Five PSA Methods Compared by Assaying Samples with Defined PSA Ratios,
- 1 May 1997
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 43 (5) , 843-845
- https://doi.org/10.1093/clinchem/43.5.843
Abstract
Prostate-specific antigen (PSA) has been established as a marker to aid in detection and monitoring of prostate cancer (1)(2). PSA in serum exists predominantly in three forms: free, uncomplexed PSA; PSA covalently complexed to α1-antichymotrypsin (PSA-ACT); and PSA covalently complexed to α2-macroglobulin (PSA-MG) (3). Immunoassays available today recognize free PSA and PSA-ACT but not PSA-MG, and their result for “total PSA” refers to the sum of the free and ACT-bound forms of PSA as measured by the immunoassay.Keywords
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