Acyl-kallikrein; a delivery system for the kinin-liberating enzyme
- 1 April 1984
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 40 (4) , 373-374
- https://doi.org/10.1007/bf01952559
Abstract
Glandular kallikrein can be temporarily acylated at the active centre by 4-amidinophenyl benzoates. The time course of reactivation depends on the nature of the acyl group introduced. Benzoyl kallikrein was used as a delivery system for kallikrein in vivo. In rabbits, bolus injection of the acylated enzyme caused a long-lasting drop in blood pressure due to sustained kinin liberation.Keywords
This publication has 9 references indexed in Scilit:
- Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapyNature, 1981
- Behavior of trypsin and related enzymes toward amidinophenyl esters.Journal of Pharmacobio-Dynamics, 1981
- Pharmacological control of blood coagulation by synthetic, low-molecular-weight inhibitors of clotting enzymes: A new concept of anticoagulantsTrends in Pharmacological Sciences, 1980
- Kallikrein inhibitors.1979
- Pharmacological Control of Hyperproteolytic States in Blood by Synthetic Inhibitors of Serine ProteinasesPathophysiology of Haemostasis and Thrombosis, 1978
- Proteolytic enzymes. 7. "Inverse substrates" for trypsin. Efficient enzymic hydrolysis of certain esters with a cationic center in the leaving groupJournal of the American Chemical Society, 1977
- Synthetic low molecular weight inhibitors of serum kallikreinBiochemical Pharmacology, 1974
- [Synthesis of antiproteolytic efficent arylcarbonyl-aralkylcarbonyl- and arylsulfonic acid esters of amidinophenols].1973
- Inhibition of trypsin and thrombin by amidinophenyl esters of aromatic carboxylic acids.1972