Correlation between phospholipase A2 activity and intra‐Golgi protein transport reconstituted in a cell‐free system
- 14 June 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 324 (2) , 201-204
- https://doi.org/10.1016/0014-5793(93)81393-e
Abstract
A wide variety of phospholipase A2 inhibitors blocks intra‐Golgi protein transport reconstituted in a cell‐free system. Phospholipase A2 activity detectable under the protein transport assay conditions is actually inhibited by the inhibitors. There is a good correlation between the inhibition of protein transport and that of phospholipase A2 activity. Prolactin secretion from GH3 cells is also blocked by a membrane‐permeable phospholipase A2, inhibitor, suggesting the physiological relevance to inhibition of protein transport in vitro by phospholipase A2 inhibitors.Keywords
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