Spiramycin Excretion in Animals: II. Repeated Oral Doses in Rats
- 1 May 1972
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 51 (3) , 712-715
- https://doi.org/10.1177/00220345720510030401
Abstract
After 7 to 14 spiramycin doses, plasma and selected tissues were assayed for residual antibiotic. Plasma contained detectable spiramycin only in samples taken 24 hours after the last 400 mg/kg dose. After 100 to 400 mg/kg levels, spiramycin remained in mandibular gingiva and bone at least seven days. Parotid and submaxillary glands contained antibiotic 24 hours after 25 to 400 mg/kg doses and 14 to 21 days after 400 mg/kg doses.Keywords
This publication has 1 reference indexed in Scilit:
- Spiramycin Excretion in Animals: I. A Single Oral Dose in RatsJournal of Dental Research, 1971